Why is it important to rotate injection sites?

Rotating injection sites is essential primarily to prevent tissue damage and ensure proper absorption of the medication. When injections are repeatedly administered in the same area, it can cause tissue irritation, inflammation, or necrosis. This can lead to complications such as lipodystrophy, where fat tissue becomes lumpy or irregular, potentially affecting how well the medication is absorbed at that site due to variability in blood flow and tissue density. By rotating sites, the body has a chance to heal and maintain healthy tissue, which supports more consistent and effective medication absorption.

While compliance with protocols, tracking used sites, and minimizing patient discomfort are important considerations, the core reason for site rotation centers around maintaining the integrity of the tissue and optimizing the delivery of medication.